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Zofran during pregnancy more than doubles the risk of atrial septal defects asd and ventricular septal defects vsd , and increases the risk of atrioventricular septal defects avsd by nearly five times.
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These changes could trigger serious abnormal heart rhythms.including torsade de pointes.a type of life-threatening rapid heartbeat that starts in the bottom chambers of the heart.
In certain illnesses and treatments where Zofran has been used.blood vessel blockage has occurred. However.it is important to note that blood vessel blockage has also occurred in these illnesses and treatments when Zofran Tablets have NOT been used. Discuss this with your doctor if you have any concerns.
Hypersensitivity reactions.including anaphylaxis and bronchospasm.have been reported in patients who have exhibited hypersensitivity to zofran over the counter substitute selective 5-HT 3 receptor antagonists. If hypersensitivity reactions occur.discontinue use of ZOFRAN. treat promptly per standard of care and monitor until signs and symptoms resolve [see Contraindications (4)].
Central Nervous System. Extrapyramidal reactions (less than 1% zofran over the counter substitute patients).
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