Zofran during pregnancy more than doubles the risk of atrial septal defects asd and ventricular septal defects vsd , and increases the risk of atrioventricular septal defects avsd by nearly five times.
Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from 2 small trials indicate that when used together, zofran may increase patient-controlled administration of tramadol.
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You should not use zofran if you are allergic to ondansetron, to similar medicines such as dolasetron anzemet , granisetron kytril , or palonosetron aloxi .